Bacteria with a silver lining

A potential silver lining for antimicrobial treatments against certain bacteria

Mycobacterium tuberculosis (Mtb) causes TB in humans and there is an increasing number of drug-resistant Mtb strains across the globe. As a result, it is important that effective anti-TB agents are available. David Alland (University of Medicine and Dentistry of New Jersey, NJ, USA) and coworkers recently reported a new class of thiophene (TP) compounds that are able to destroy Mtb via Pks13 in...

HIV cardiomyopathy: a dark cloud with a silver lining?

A wide variety of cardiac problems have been reported in patients infected with the human immunodeficiency virus (HIV). These include pericardial effusion, pulmonary hypertension and right heart failure, infective endocarditis, and tumours such as lymphoma and Kaposi's sarcoma.' However, left ventricular dysfunction caused by myo-carditis or cardiomyopathy is emerging as the most important card...

Every silver lining has a cloud.

Every cloud has a silver lining.

phamide, and Rituximab Versus FCR Alone in Subjects With Relapsed Chronic Lymphocytic Leukemia] study).8 If the results of this pivotal trial confirm the findings of Byrd et al,7 it will have an important influence on the treatment strategy of patients with CLL. In recent years, 4 drug combination therapies with FCR and alemtuzumab or FCR and mitoxantrone in refractory/relapsed CLL patients wer...

The Silver Lining of Cloud Computing

“Due to decades of technology acquisitions to fuel growing businesses, enterprises are now facing a breaking point with their IT systems. Some systems can’t share information and workloads, servers are highly underutilized and the cost of energy is becoming greater than the value of the systems the energy powers. In some cases, nearly 70 percent of companies’ IT budgets can be devoted to managi...